Charleston starter Jimmy Revan pitched 4.1 innings and allowed just three earned runs and struck out five in his first career start. Senior Drew Freie (1-0) picked up the win with 2.2 innings of relief, striking out four and allowing just one hit and one run.
Charleston Southern's Stephen Leopard (0-1) was tagged with the loss after giving up eight runs, four earned, in the first 2.2 innings.
College of Charleston's (3-1) hit and run output was the largest of the season so far as the Cougars scored runs in all but two innings.
"I was really pleased with our offense tonight," head coach Monte Lee said. "We got great offensive production from a lot of different guys tonight which was great to see. We are looking forward to facing three quality opponents at Auburn this weekend."
Heidt pushed his season average to .400 with his home run and triple. Along with his career-best four RBI, he also scored two runs. Murray extended his SoCon-best hitting streak to 15 games with a two-run double in the first inning.
Glazer followed Murray with his own RBI double, and the Cougars led 3-0 after the first inning. Heidt's two-run homer scored freshman Blake Butler in the second inning, and an error in the third inning allowed Cody Martin and Glazer to score. College of Charleston built an 8-0 lead after three innings, and CSU never got closer than four runs for the rest of the game.
Junior Ryan Welke scored a career-high three runs as he drove two in with two hits, including his first double of the season. Freshman Blake Butler earned his first career start at second base and he went 1-for-2 with a double, an RBI and a run scored.
Wise entered the game as a pinch-hitter and knocked his first career hit, a solo home run to dead center field.
Charleston Southern (2-2) was led by Robbie Streett's two RBI and Nick Berry's two hits. Jaren Sustar knocked an RBI triple and scored two runs.
Tuesday's game was played at College of Charleston after rain in the area forced both teams to move it from its previously scheduled venue at Charleston Southern. CofC will now play at Charleston Southern on March 6 at 2 p.m.
College of Charleston will travel to Auburn, Ala., this weekend for a three-game tournament against Indiana State, Auburn and Middle Tennessee State.