Charleston (5-4) scored 12 runs for the second straight game, while South Alabama's (9-1) only two runs came after two CofC errors in the eighth inning.
Bradley Goodson and Blake Butler each tallied three hits, while Gunnar Heidt and Alex Pastorius both had three RBIs apiece. Ryan Welke hit his first home run of the season, while Heidt's three RBI came on a bases-clearing triple, his third of the season.
"We had a great offensive output all the way through the lineup," head coach Monte Lee said. "We have been stressing having quality at-bats and we did that tonight. Matt Pegler also came out and gave us a great start. Tonight was a good way to start the series."
Senior Matt Pegler (1-0) picked up his first win of the season with a seven-inning, two-hit performance. He did not allow a Jaguar run to improve his season ERA to 0.48, and also struck out seven batters while walking just one.
South Alabama starter James Traylor (1-1) gave up five earned runs on five hits through 3.1 IP to take his first loss of the season.
The Cougars jumped on the scoreboard in the second inning after two infield errors from the Jaguars. Blake Butler and Goodson scored runs after a two-out throwing error from Bud Collura that would have ended the inning.
CofC extended the lead in the fourth inning with an RBI single from Butler and a bases-loaded walk from Pastorius. Heidt then unloaded the bases with a triple to the wall in right field, giving the home team a 5-0 lead. It was his third triple of the season which leads the Southern Conference.
After a leadoff walk to Ben Boykin in the seventh inning, Welke hit a bomb to right field for his first home run of the season and just the second homer of his career. After three straight singles, Cody Martin grounded out to score Goodson and then Pastorius drove in two more with a single to center field, pushing the lead to 12-0.
South Alabama got on the scoreboard in the eighth inning after two CofC errors allowed the first two batters to reach. Cole Billingsley tallied an RBI on a fielder's choice and Jeff DeBlieux registered a sacrifice fly RBI to score Hayden Jones. CofC freshman Player Loving eventually got out of the inning with a bases-loaded strikeout.
The Cougars will go for the series win tomorrow with a 2 p.m. start against South Alabama. LHP Jake Zokan will start for CofC against USA's LHP Jacob Noble.