With the win, Clemson moved to 28-19 on the season while the Cougars go to 31-15 on the season and 0-2 in the series.
Despite tallying eight hits, the Cougars did not get on the scoreboard until the eighth inning when Brandon Murray hit a three-run home run to right field for CofC's only runs.
Clemson starter Kevin Pohle (5-2) pitched seven shutout innings and struck out five batters to earn the victory. Pohle had to work out of trouble in numerous innings as he stranded six Cougar runners and scattered six hits.
CofC's Josh Renfro (6-5) picked up his second straight loss as he worked 4.0 innings and allowed four runs, three earned, on six hits.
The Tigers' Thomas Brittle and Richie Shaffer each tallied three hits and combined for three runs and three RBI. Brittle and leadoff batter Steve Wilkerson hit back-to-back triples to lead off the eight-run seventh inning. Spencer Kieboom and Brad Felder each tallied two RBI.
Murray led the Cougar offense with his three-run homer in the eighth inning that scored Marty Gantt and Bradley Goodson. Gantt tallied a hit and two walks on the day. Brandon Glazer hit a single to extend his team-best hitting streak to 13 games, while Jimmy Holton tallied two hits for the Cougars.
The Tigers got on the board in the second inning when a hard hit ball ate up Goodson at short and allowed Jay Baum to score, unearned, with two outs. Clemson scored its second run two innings later on another two-out ball hit hard at an infielder as Felder was credited with the RBI single to score Baum and make it 2-0.
The Cougars had runners in scoring position in the second, third, fourth and fifth innings but could not get the runners home.
Clemson added two runs in the fifth off hits from Brittle and Shaffer, and then put the game away with the eight-run seventh inning which featured seven hits and one Cougar error.
The final game of the series will start at 4 p.m. on Monday afternoon. The Cougars will start RHP Matt Pegler while the Tigers will counter with RHP Jonathan Meyer.